Synthesis of Some Heterocyclic Compounds Derived From 2-Amino Benzothiazole

Abstract

In this thesis, Anmber of heterocylic compound with five and six memberd, Such as substituted imidazole, triazin and thiazolidine. The N-(1,3-benzothiazol-2-yl)-2-chloro acetamide compound(1) was prepared from the reaction of the compound (2-amino benzothiazole) with chloroacetyl chloride. The product(1) was reacted with thiourea and urea to prepare both (imidazole -2-thione (2) and imidazole -2-one(3)) , respectively. As did compound(1) with thiosemicarbazide and semicarbazide to prepared the two compounds (1,2,4-triazine -3-thione (4) and 1,2,4-triazine -3-one (5)) ,respectively. Also compound(1) with ammonium thiocyanate to prepare the compound thiazolidin -4-one (6). From the reaction of compound(1) with phenyl thiourea attended imidazole -2-thione(7). Also from the reaction of (2-amino benzothiazole) with phthalic anhydride or malic anhydride attended compounds (8) and (9) ,respectively. And by reaction compound(8) or (9) with o-phenylene diamine attended compounds (10) and (11) ,respectively. The synthesized compounds are identified by physical (melting points, colour change) and spectral methods such as (IR, proton-NMR).