Abstract
Synthesis of 4-arylidene-5-methyl-2,4-dihydro-3 H -pyrazol-3-one ( IIIa-d ) has been achieved by the condensation reaction between 5-methyl-2,4-dihydro-3 H -pyrazol-3-one ( I ) and 4-substituted benzaldehydes ( IIa-d ). Ethyl acetoacetate and hydrazine hydrate in absolute alcohol undergo cyclization reaction to give ( I ). 4-Arylidene-5-methyl-2,4-dihydro-3 H -pyrazol-3-ones ( IIIa-d ) have been converted to corresponding ethoxyphthalimide derivatives ( IVa-d ) by treatment with phthalimidoxyethyl bromide ( A ). 1-N-Ethoxyphthalimido-3-methyl-4-(4-substituted benzylidene) pyrazol-5-one ( IVa-d ) has been reacted with hydroxylamine hydrochloride and guanidine nitrate separately to yield ethoxyphthalimide substituted pyrazolo[3,4-c]isoxazoles ( Va-d ) and pyrazolo[3,4-d]pyrimidines ( VIa-d ) respectively. All the compounds have been characterized by elemental and spectral analysis mainly IR, 1 H NMR and mass spectroscopy. Synthesized compounds have also been screened for various biological activities viz. antibacterial, antifungal, antiviral and anticancer.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
