Abstract
AbstractReaction between 6‐methoxy‐1‐tetralone, methyl propiolate and an ammonia‐saturated methanolic solution led to 5,6‐dihydro‐8‐methoxybenzo[h]quinolin‐2(1H)‐one in good yields. Subsequent aromatization, chlorination, substitution and demethylation enabled us to prepare 2‐amino‐substituted benzo[h]quinoline derivatives. These compounds, which are structurally related to the antitumor benzo[c]phenanthridine alkaloids by deletion of a ring, were tested on cultured murine lymphoblastic leukaemia cells (L1210). Results showed that they are devoid of cytotoxicity.
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