Abstract
Four cyclopeptides containing disulfide linkages were efficiently synthesized using DCC as coupling reagent under highly dilute conditions.
Highlights
Cyclic peptides have been characterized in many natural environments, and show a wide spectrum of biological activity.[1]
The covalent cross-linking of two nonadjacent cysteine residues in a peptide chain results in the formation of well-defined loops of the type Cys- (X)n-Cys
Considerable effort has been directed toward the conformational analysis of larger-membered cyclic peptide disulfides
Summary
Cyclic peptides have been characterized in many natural environments, and show a wide spectrum of biological activity.[1]. The residue was taken up in CH2Cl2, the organic layers were washed successively with 0.5 M HCl, saturated NaHCO3, brine and dried over Na2SO4 and concentrated in vacuo to yield a light yellow solid. MeO-(S-Acm)Cys-(N-Boc)-Asp-γ-(S-Acm)Cys-OMe (2b) was obtained according to the procedure leading to 2a.
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