Synthesis of ( S)-2-Boc-Amino-8-( R)-( tert-butyldimethylsilanyloxy)decanoic acid, a precursor to the unusual amino acid residue of the anticancer agent microsporin B

Abstract

( S)-2-Boc-Amino-8-( R)-( tert-butyldimethylsilanyloxy)decanoic acid, the Boc-protected precursor of an unusual amino acid residue for the synthesis of microsporin B, was synthesized. The key steps include a Suzuki coupling followed by asymmetric homogeneous hydrogenation.