Abstract
In the present paper, a fast and reproducible method for the synthesis of S-[ 13N]nitrosoglutathione is reported for the first time. The labeling strategy is based on the production of [ 13N]NO 3 − via the 16O( p, α) 13N nuclear reaction in water, as opposed to the standardized production of [ 13N]NH 4 + in 2 mM aqueous ethanol. Following the reduction of [ 13N]NO 3 − to [ 13N]NO 2 −, the reaction with glutathione in the presence of hydrochloric acid led to the desired radiotracer with a good radiochemical yield (24.2±2.0% end of synthesis, n=5) in a short production time (3 min from the end of bombardment).
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