Abstract
As discussed in this Symposium by Dr. Alberts, there appear to be two kinds of initiation of DNA synthesis: (1) primary initiation from a specific site (origin or ori site) on double-stranded DNA leading to the formation of a replication fork, and (2) frequent discontinuous initiations restricted mainly to the “lagging” strand of DNA within the moving fork and leading to the formation of socalled Okazaki fragments. The first step in both kinds of initiation probably involves the synthesis of an RNA primer, since DNA polymerases require the 3’-OH terminus of a pre-existing primer, and RNA polymerase can initiate RNA synthesis from a DNA template without a primer.
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