Abstract
SYNTHESIS OF RADIOACTIVE FATTY ACIDS IN VITRO AND ITS HORMONAL CONTROL
Highlights
SYNTHESIS OF RADIOACTIVE FATTY ACIDS IN VITRO AND ITS HORMOSAL CONTROL*Stetten and coworkers (4-G) found, with the aid of heavy water, that the normal conversion of 35 to 50 per cent of ingested carbohydrate to fat was strikingly diminished in the diabetic animal
Brady, Lukens, and Gurin [10] demonstrated that the removal of the hypophysis as well as the pancreas was gccompanied by a restoration of hepatic lipogcnesis to a normal rate, in contrast with the depression caused by pancreatectomy alone
It is the purpose of this communication to report the general .effects of the secretions from the pituitary, adrenal, and pancreas on fatty acid synthesis, and to demonstrate the influence of purified growth hormone, 17-hydroxy-ll-dehydrocorticosterone, and insulin upon these biosynthetic processes
Summary
Stetten and coworkers (4-G) found, with the aid of heavy water, that the normal conversion of 35 to 50 per cent of ingested carbohydrate to fat was strikingly diminished in the diabetic animal They observed that t’he prior administration of insulin to the animal increased hepatic lipogenesis. Brady, Lukens, and Gurin [10] demonstrated that the removal of the hypophysis as well as the pancreas was gccompanied by a restoration of hepatic lipogcnesis to a normal rate, in contrast with the depression caused by pancreatectomy alone It is the purpose of this communication to report the general .effects of the secretions from the pituitary, adrenal, and pancreas on fatty acid synthesis, and to demonstrate the influence of purified growth hormone, 17-hydroxy-ll-dehydrocorticosterone (cortisone), and insulin upon these biosynthetic processes.
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