Abstract
Spirocyclopentanone–anthracene adducts, novel antimalarial agents, have been synthesized by employing the racemic and the optically active dimethyl itaconate–anthracene adducts in a reaction with piperine via tandem Michael addition–Dieckmann condensation reactions as the key steps. All adducts exhibited antimalarial activity with IC50 values of 3.4–4.7μg/mL, and importantly displayed non-cytotoxicity to vero cells.
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