Abstract
Boron-containing analogues of ether lipids are proposed as boron carriers in the boron neutron capture therapy (BNCT). The synthesis of rac-1-(9- o-Carboranyl)nonyl-2-methyl-glycero- 3-phosphocholine (B-Et-11-OMe) as a first representative is described. The carborane is introduced into the readily assembled glycerol ether moiety. The phosphocholine headgroup is introduced by 2-chloro-3-methyl-1,3,2-λ 3-oxazaphospholane using a phosphoamidite strategy and subsequent ring opening under alkylating conditions.
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