Abstract
Orphenadrine is an antihistamine and anticholinergic drug. Sälinger and Brückner report a short synthesis of (R)-orphenadrine that features the first asymmetric ligand-accelerated halogen-metal exchange in which the pro-S bromoarene of the substrate B reacts faster than the pro-R bromoarene leading to kinetic selection for the organomagnesium derivative D. Simple protonolysis of D gave the key intermediate E.
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