Abstract
Article history: Received October 25, 2012 Received in Revised form December 6, 2012 Accepted 19 January 2013 Available online 19 January 2013 Efficient synthesis of quinoxaline derivatives from the reaction of α-diketones and ophenylenediamines in the presence of Keggin-type heteropolyacids (HPA) such as H3PMo12O40, H4SiW12O40, K7PMo2W9O40, H3PW12O40.SiO2 and H3PW12O40 in high yields and short reaction times, and at room temperature is introduced. © 2013 Growing Science Ltd. All rights reserved.
Highlights
Acids as solid acid catalysts are green catalysts with respect to their non-corrosive nature, safety, low quantity of waste and easy separation
The best reported method for synthesis of quinoxalines is the reaction of aryl 1,2-diamines with a 1,2-dicarbonyl compounds in the presence of an acid as catalyst
In continuation of our investigations on the applications of solid acids in organic synthesis, we have investigated the synthesis of quinoxalines in the presence of heteropoly acid at room temperature
Summary
Acids as solid acid catalysts are green catalysts with respect to their non-corrosive nature, safety, low quantity of waste and easy separation. One of the unique features that make solid heteropoly acids economically and environmentally attractive is their stability and high acidity. Quinoxalines are important heterocycles in medicinal chemistry[1,2] and have biological activities such as antibacterial and anti-inflammatory activities[3,4]. The best reported method for synthesis of quinoxalines is the reaction of aryl 1,2-diamines with a 1,2-dicarbonyl compounds in the presence of an acid as catalyst. Acetic acid[5], iodine[6], CuSO4.5H2O7, Zn[(L)-proline]8, Ni-nanoparticles[9], gallium(III)triflate[10], montmorillonite K1011, task-specific ionic liquids[12], MnCl213, and ZrO2/Ga2O3/MCM-4114 and alumina-supported heteropolyoxometalates[15] have been applied in the above mentioned method
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