Synthesis of Quinoxaline Derivatives via Copper(I)-Catalyzed Cross-Coupling Reaction of 1,2-Dihalobenzenes with N,N′-Disubstituted Ethane-1,2-diamines under Ligand- and Solvent-Free Conditions

Abstract

An efficient ligand- and solvent-free method for the synthesis of quinoxaline derivatives via copper(I)-catalyzed cross-coupling process has been developed. 1,2-Halobenzenes or 1,8-diiodonaphthalene coupled with N,N′-disubstituted ethane-1,2-diamines to give the corresponding products in moderate yields under the reaction conditions.