Abstract

以2-羟基查尔酮与4-羟基-2（1 H ）-喹啉酮或4-羟基-2（1 H ）-吡啶酮在正丙醇中回流反应，立体选择性地合成了喹啉酮和吡啶酮稠合的2，8-二氧杂双环[3.3.1]壬烷衍生物.其中，喹啉酮片段通过烷基化反应可转化为相应的氮烷基取代的喹啉酮和氧烷基取代的喹啉结构.目标产物均未见文献报道，其结构都通过了 1 H NMR、 13 C NMR、IR和HRMS的表征，6-苯基-2，12-二氢-1 H -6，12-亚甲基苯并[7，8][1，3]二氧桥[5，4- c ]吡啶-1-酮（ 3r ）和1-异丙氧基-8-苯基-14 H -8，14-亚甲基苯并[7，8][1，3]二氧桥[5，4- c ]喹啉（ 6c ）的结构和立体构型还进一步获得了X射线单晶衍射的证实.

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