Synthesis of Quinoline Analogues as Anti-microbial Agents

Abstract

Various substituted Quinoline containing different functional group have been synthesized by conventional method. The quinoline derivative is synthesized by using 8-hydroxy quinoline) was first treated with ethyl chloroacetate to form ester intermediate which was subsequently treated with Hydrazine Hydrate result into formation of Hydrazone derivative then this intermediate was made to react with substituted benzoic acid. The final structures have been established on the basis of their chemical analysis and spectral data. Final compounds were further evaluated for in-vitro anti-microbial activity using standards.