Synthesis of Quinazolinones from Alcohols via Laccase‐Mediated Tandem Oxidation

Abstract

AbstractThis paper describes the synthesis of quinazolinones via a tandem reaction using the laccase‐mediator system under mild conditions. The procedure involved the laccase‐catalyzed oxidation of alcohols to the corresponding aldehydes, followed by cyclocondensation with isatoic anhydride and a number of amines to afford 2,3‐dihydroquinazolin‐4(1H)‐ones, which were further oxidized to quinazolinones in useful yields. The use of an enzyme as the catalyst, O2 as an environmentally friendly oxidant, and a citrate buffer as the green solvent represents a novel and efficient approach for the one‐pot synthesis of quinazolinones.magnified image