Abstract
ABSTRACTAn eco-friendly advanced strategy developed for the synthesis of quinazolinone derivatives catalyzed by using triethanolamine (TEOA) as a catalyst with the addition of NaCl in presence aqueous media under reflux condition via a one-pot multicomponent reaction. The addition of NaCl controls the formation of micelles and increase the hydrophobic interaction. It is interesting to note that TEOA in combination with NaCl showed excellent selectivity not only in forming the desired product but also in directing the reaction to proceed in a very cleaner way. Valuable features of this protocol including simple reaction condition, excellent yield, broad substrate scope, and easy work-up procedure make this an efficient and promising synthetic approach for the synthesis of quinazolinone derivatives.
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