Abstract
In this study, we reported a simple and efficient route for the one-pot sonochemical synthesis of substituted 3-pyrrolin-2-ones by citric acid as an additive.
Highlights
In recent years, there has been increasing interest in the applications of multicomponent reactions (MCRs) in modern synthetic organic chemistry
Considering the importance of clean chemistry, in this study we have developed a new methodology for the synthesis of substituted 3-pyrrolin-2-ones in the presence of citric acid as a green additive in a green solvent under ultrasound irradiation (Scheme 1)
Our research was focused on the verification of pyrrolidinones synthesis via a convenient and easy method
Summary
There has been increasing interest in the applications of multicomponent reactions (MCRs) in modern synthetic organic chemistry. Ultrasound irradiation has been established as a significant technique in synthetic organic chemistry, where it has been applied as an efficient energy and heating source for organic reactions.[16,25,26,27] To achieve suitable conditions for the synthesis of substituted 3-pyrrolin-2-ones (4a–p), various reaction conditions were investigated for the reaction of aniline, diethyl acetylenedicarboxylate, 4-chlorobenzaldehyde and citric acid as a green additive in ethanol solvent as a model reaction.
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