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Abstract
To concisely synthesize highly enantiomerically enriched 5-alkyl-substituted pyrrolidine-3-carboxylic acids, organocatalytic enantioselective Michael addition reactions of 4-alkyl-substituted 4-oxo-2-enoates with nitroalkanes have been developed. Using the developed reaction method, 5-methylpyrrolidine-3-carboxylic acid with 97% ee was obtained in two steps.
Highlights
Correction for ‘Synthesis of pyrrolidine-3-carboxylic acid derivatives via asymmetric Michael addition reactions of carboxylate-substituted enones’ by Feng Yin et al, Org
The correct structure was determined by the X-ray crystal structural analysis of a derivative of 3, which will be reported separately in the future
The authors noticed that in 5-membered ring systems, NOE signals in NOESY spectra can be observed between a proton attached to a carbon on the 5-membered ring and a substituent at the second carbon from the proton-attached carbon on the same ring, even when they are in the trans relationship
Summary
Correction for ‘Synthesis of pyrrolidine-3-carboxylic acid derivatives via asymmetric Michael addition reactions of carboxylate-substituted enones’ by Feng Yin et al, Org. Correction: Synthesis of pyrrolidine-3-carboxylic acid derivatives via asymmetric Michael addition Chem., 2018, 16, 3052 reactions of carboxylate-substituted enones
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