Synthesis of Pyrroles and Thiazolanes Promoted by N-Methylimidazole in Water

Abstract

A convenient and efficient approach to the synthesis of substituted pyrroles is reported based on three-component reaction of primary amines and alkyl propiolates in the presence of N-methyl­imidazole in water. A water-accelerated synthesis of thiazolane derivatives has also been established by employing the three-component reaction of primary amines, alkyl propiolates, and isothiocyanates in the presence of N-methylimidazole.