Abstract
Abstract Fe3O4@SiO2-L-proline nanoparticles have been used as an effective catalyst for the preparation of pyrimidines by three-component reactions of 1,3-dimethylbarbituric acid, aromatic aldehydes and 4-methyl aniline or 4-methoxy aniline under reflux condition in ethanol. Fe3O4@SiO2-L-proline nanoparticles have been characterized by scanning electronic microscopy (SEM), powder X-ray diffraction (XRD), vibrating sample magnetometer (VSM), thermal gravimetric analysis (TGA), energy dispersive X-ray (EDS), dynamic light scattering (DLS) and FT-IR spectroscopy. This method provides several advantages including, the reusability of the catalyst, low catalyst loading, atom economy, short reaction times and high yields of products.
Highlights
Pyrimidines have many biological properties including anticancer (Singh et al, 2009), anti-diabetic (Barakat et al, 2015), antioxidan (Barakat et al, 2016), antibacterial, anti-fungal (Dhorajiya et al, 2014), and anticonvulsant (Andrews et al, 1979)
The synthesis of pyrimidine derivatives have been developed by InCl 3 (Sharma et al, 2015), H PW O (Panahi et al, 2013), K CO
The process of the preparation Fe O @SiO -L-proline nanoparticles is shown in Scheme 2
Summary
Pyrimidines have many biological properties including anticancer (Singh et al, 2009), anti-diabetic (Barakat et al, 2015), antioxidan (Barakat et al, 2016), antibacterial, anti-fungal (Dhorajiya et al, 2014), and anticonvulsant (Andrews et al, 1979). We report the use of nano-Fe O @SiO -L-proline as an effective catalyst for the synthesis of pyrimidines by three-component reactions of 1,3-dimethylbarbituric acid, aromatic aldehydes and The process of the preparation Fe O @SiO -L-proline nanoparticles is shown in Scheme 2.
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