Abstract
AbstractBenzodiazepines show a broad spectrum of biological activities. In an ongoing effort to extend molecular diversity in this type of systems, we developed a strategy for synthesizing3,4‐dihydro‐1H‐pyrido[2,3‐e][1,4]diazepine‐2,5‐dione compounds starting from 2‐hydroxynicotinic acid and by using an Ugi reaction as a key step in the synthesis. We opted to use 2‐isocyanophenyl benzoate instead of Armstrong's convertible isocyanide in this multicomponent reaction.
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