Abstract
Pyridopyrimidine-2,4(1H,3H)-diones and pyrido[4,3–d]pyrimidine-2,4,5(1H,3H,6H)-triones are valuable scaffolds which can be used in drug development. In this letter a simple and efficient method for the synthesis of pyrido[4,3–d]pyrimidine-2,4-diones and pyrido[4,3–d]pyrimidine-2,4,5(1H,3H,6H)-triones by oxidative aromatization of easily synthesized 5,6,7,8-tetrahydropyrido[4,3–d]pyrimidine-2,4(1H,3H)-dione derivatives was reported.
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