Abstract
Five kinds of N1-(2-methyl-3-oxo-2, 3-dihydro-4(or 5)-pyridazinyl) sulfanilamides were prepared starting from chloromaleic anhydride. In addition, three kinds of N1-(2-methyl (or phenyl)-3-oxo-2, 3-dihydro-4 (or 5)-pyridazinyl) sulfanilamides were also prepared. It is of interest that of these sulfonamides prepared, those substituted with the sulfanilamide group at 4-position of pyridazine nucleus have shown marked activities in vitro.
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