Abstract
The designed and synthesized 2-(4-methoxyphenyl) ethyl] acetamide derivatives ( 3a, 3b and 3c) were evaluated for their PTP1B inhibitory activity where they showed IC 50 values 69 μM, 87 μM and 71 μM, respectively. These results correlated well with the docking studies and in vivo screening of the compounds for their antidiabetic activity in SLM and STZ models.
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