Abstract
Slices of porcine corpora lutea incubated in vitro incorporate acetate-l-14C into progesterone and 20α-hydroxy-4-pregnene-3-one. Progesterone-14C synthesis is greatest in tissues Obtained from animals in midcycle or early pregnancy. Incubation of porcine luteal slices in the presence of LH gives a significant increase (p <0.001) in progesterone concentration above control levels. No significant difference between ovine, bovine, or porcine LH was seen. The mean values were: control 202, porcine LH 233, bovine LH 249, and ovine LH 245 μg/g tissue, with approximately 50 flasks/treatment group. By using suitably increasing concentrations of LH (0.004–0.1 μg/ml) a graded increase in progesterone concentration was obtained. Whereas progesterone synthesis in vitro is stimulated by LH (p < 0.001), it is not influenced by FSH or prolactin (values: control 200, LH 222, FSH 194, prolactin 196 μg/g tissue; 36 flasks/treatment group). The increase in progesterone concentration induced by LH is greater in tissues obtai...
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