Synthesis of Primary Thioamides from Nitriles and Hydrogen Sulfide Catalyzed by Anion‐Exchange Resin.

Abstract

A new method has been developed for converting nitriles into primary thioamides. Treatment of various nitriles (Table 1, entries 1-12) with gaseous hydrogen sulfide in a mixture of methanol-water or ethanol-water and in the presence of anion-exchange resin (Dowex I XX. SH form) at room temperature and ambient pressure gave the corresponding thioamides in 25-96% yield.