Abstract
Thirteen compounds having a 2-aza- or a 7-azabicyclo[2.2.1]heptane framework substituted at the 3-position by a prostanoic chain have been synthesized from easily obtained hetero-Diels–Alder adducts; owing to their structure, a TxA2 antagonist activity was expected for these compounds with consequences for platelets aggregation and/or blood pressure, and these effects were effectively observed for some of them but with lower activity than previously described molecules.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
