Abstract
Novel pentasubstituted pyrroles containing a propanoic acid fragment in position 1 were obtained by the reaction of arylglyoxals, N,Ndimethylbarbituric and 3-[(4-oxopent-2-en-2-yl)amino]propanoic acids both by sequential introduction of reagents and the one-pot method. The three-component condensation of phenylglyoxal, N,N-dimethylbarbituric acid, and 3-aminocrotonate afforded 3-carboxyethyl-2-methyl-5-phenylpyrrole with a pyrimidine fragment in position 4.
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