Synthesis of Polyoxygenated Biphenyls

Abstract

Background: Construction of biaryls containing polyoxygenated groups via the palladiumcatalyzed Suzuki-Miyaura cross-coupling reaction of aryl halides with organoboronic acids is a very interesting area of research. A number of functionalized polyoxygenated biphenyls have received considerable attention during the past decades, due to their presence as the structural motifs in natural products with diversified biological activities. Due to the particular pharmaceutical interest concerning the specific substitution pattern of a biphenyl scaffold, several synthetic methods have been developed. On the basis of investigation, we developed a novel Suzuki-Miyaura cross-coupling route for preparing polyoxygenated biphenyls. Keywords: Baeyer-Villiger deformation, Claisen rearrangement, Olefin migration, Oxidative cleavage, Polyoxygenated biphenyls, Suzuki- Miyaura cross-coupling.