Abstract
Synthesis of polyhydroquinoline derivatives under aqueous media without catalyst
Highlights
The environmental acceptability of the process is improved if the multi-component strategy is applied
It is well known that multi-component reactions (MCR), consisting of two or more synthetic steps, which are carried out without isolation of any intermediate, allow to reduce time, save money, energy and raw materials.[1]
We wish to report a simple, environmentally benign and efficient method for the one-pot synthesis of polyhydroquinoline derivatives from the reactions of aldehydes, dimedone, ethyl acetoacetate and ammonium acetate in refluxing water (Scheme1)
Summary
The environmental acceptability of the process is improved if the multi-component strategy is applied. We wish to report a simple, environmentally benign and efficient method for the one-pot synthesis of polyhydroquinoline derivatives from the reactions of aldehydes, dimedone, ethyl acetoacetate and ammonium acetate in refluxing water (Scheme[1]).
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