Abstract
The reactivity of (poly)halo‐substituted benzenesulfonyl chlorides in palladium‐catalyzed ortho‐directed C–H bond sulfonylation of 2‐arylpyridines was investigated. The use of Ag2CO3 in concert with Cu(OAc)2 was found to be critical to promote the chemoselective sulfonylation reaction. Fluoro‐, chloro‐, bromo‐, and even iodo‐benzenesulfonyl chlorides react nicely to afford halo‐substituted diarylsulfones in good to high yields without cleavage of the C–halo bonds, allowing further transformations.
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