Synthesis of Poly(3,4,5-trihydroxybenzoate amide) and Poly(3,4,5-trihydroxybenzoate ester) Dendrimers from Polyphenols and Their Chemiluminescence

Abstract

luminescence (CL) flow injection system. The CL intensities of polyphenols are considerably weaker than those of luminal and acridinium ester, which are representative CL compounds. Hence, trans-4-(3-propionic acid) phenylboronic acid and 4-biphenylboronic acid in the presence of peroxidase or 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide have been used as an enhancer for highly sensitive polyphenol CL determination. However, methods to derive polyphenols with strong CL intensity have not been reported yet. 18 In recent times, after a new polymer, poly(amidoamine) dendrimer, was synthesized, dendrimers have been applied to material engineering based on optics in nanoscale science. The poly(propylene amine) family that was functionalized in the periphery with fluorescent dansyl units interacts with Co 2+ . More recently, acridinium dendrimers have been conjugated with bovine serum albumin, and its CL was estimated to be six times that of the acridinium salt. In this paper, we report the design of new types of polyphenol dendrimers having an increased number of chemiluminophores for high CL intensity; they also have hydroxyl groups in their periphery to form hydrogen bonds with an analyte. Polyphenol dendrimers having GA in the periphery were synthesized, and their CL was measured. We synthesized first-generation polyphenol dendrimers with GA units in the periphery by employing a divergent method using phenol, pyrocatechol, resorcinol, hydroquinone, 1,2,4-tri