Abstract
A series of small molecules containing polar aromatic substituents and alkynes have been synthesized. One–pot preparations of polar aromatic molecules containing an alkynyl imine and alkynyl amide are reported. A one-pot preparation of a catechol containing an alkynyl amine was also attempted but in our hands it proved much better to synthesize this target molecule via a three step synthesis which we also report here.
Highlights
A series of small molecules containing polar aromatic substituents and propargyl amines were synthesized so that they could potentially be incorporated into hydrogel amines were synthesized so that they could potentially be incorporated into hydrogel systems as an approach to developing a better hydrogen bonded and more rigid hydrogel systems as an approach to developing a better hydrogen bonded and more rigid hydrogel via a thiol-alkyne click reaction [1,2,3,4,5,6]
ConclusionsWe successfully prepared a number of new polar aromatic substituted terminal alkynes from propargyl amine and we hope scientists working with thiolated hydrogels will incorporate them into their hydrogels and that they will be used in pharmaceutical chemistry, with the anticipation that those modified molecules will have interesting new properties
Summary
A series of small molecules containing polar aromatic substituents and propargyl. A series of small molecules containing polar aromatic substituents and propargyl amines were synthesized so that they could potentially be incorporated into hydrogel amines were synthesized so that they could potentially be incorporated into hydrogel systems as an approach to developing a better hydrogen bonded and more rigid hydrogel systems as an approach to developing a better hydrogen bonded and more rigid hydrogel via a thiol-alkyne click reaction [1,2,3,4,5,6]. Ease synthesis of the small molecule, where the thiol-alkyne thiol-alkyne click ease ofof synthesis of the small molecule, i.e., i.e., where possible, one-potreactions reactionsfrom frominexpensive, inexpensive, commercially available starting materials.
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