Synthesis of Piperazin-2-one Derivatives via Cascade Double Nucleophilic Substitution

Abstract

AbstractA cascade, metal-promoted transformation utilizing chloro allenylamide, primary amine, and aryl iodide afforded piperizinones in good yields. Under the optimized conditions the cascade is performed as a one-pot process allowing the formation of three bonds. The synthetic route, controlled by the reaction rates of several processes involved, introduces two points of diversity and is well suited for combinatorial synthesis or related technologies.