Abstract

Pinnaic acid, isolated from the Okinawan bivalve Pinna muricata, inhibits activity of cytosolic 85 kDa phospholipase (cPLA2) and therefore has anti-inflammatory potential. Markworthy steps of the synthesis are: (1) a Pd-catalyzed trimethylenemethane [3+2] cyclization (B→D) and (2) a tandem hydrogenation-cyclization (I→J).

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