Abstract
As part of ongoing research programme on bicyclic heterocycles [1,2,3,4] we have elaborated a new approach to 1H-pyrazolo[4,3-e][1,2,4]triazine derivative 3 and its synthetic precursor 2 by reaction of oxime 5-acetyl-3-(methylsulfanyl)-1,2,4-triazine (1) with phenylhydrazine hydrochloride under different reaction conditions.[...]
Highlights
To a solution of the oxime 1 (184 mg, 1 mmol) and phenylhydrazine hydrochloride (288 mg, 2 mmol) in ethanol (10 ml) 37% HCl (0.3 ml) was added
The solid was collected by filtration, washed with water and recrystallized from ethanol/water mixture (1:1) to give 2 in 27% yield
The mixture was heated at reflux for 5 hours and the 1 von 2
Summary
To a solution of the oxime 1 (184 mg, 1 mmol) and phenylhydrazine hydrochloride (288 mg, 2 mmol) in ethanol (10 ml) 37% HCl (0.3 ml) was added. The mixture was heated at 40 oC for 9 hours and the solvent was evaporated in vacuo.
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