Abstract
Abstract A new series of diphosphonates (I) was synthesized and investigated for their pharmacological activity. 2-Substituted-1,3-propylidene diphosphonates (I) were prepared by reaction of sodium dialkyl phosphite or trialkyl phosphite with ditosylates of 2-substituted-1,3-propanediol or 2-substituted-1,3-dibromopropane. Pharmacological screenings of these 1,3-propylidenediphosphonates have shown that these compounds have potent cardiovascular activity and are potentially useful in the treatment of hypertension.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callMore From: Phosphorus, Sulfur, and Silicon and the Related Elements
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
