Synthesis of Peptide Mimetics and Amino Acid Mimetics Bearing Aminoxy Instead of Amino Group

Abstract

The compounds composed of sequential units different than amino acids might have different functionality from those of peptides. In this study, we have chosen a structure (-N-O-C-C-) as one of the sequential units and attempted to prepare the building blocks analogous to amino acids in peptides. Those building blocks, amino acid mimetics, bear an aminoxy group (H2N-O-) instead of the α-amino group (H2N-) in amino acids. Such new amino acid mimetics and the peptide mimetics constructed from those would be interesting in the studies of chemical reactivity and structure as well as bioactivity.