Synthesis of Pd(II) coordination complexes of ( S)-4-isobutyl-2-methyl-2-oxazoline and ( S)-2-(2,2-dimethylpropyl)-4-isopropyl-2-oxazoline

Abstract

( S)-4-Isobutyl-2-methyl-2-oxazoline ( 1) was obtained from ethyl acetimidate hydrochloride and l-leucinol in 81% yield. ( S)-2-(2,2-Dimethylpropyl)-4-isopropyl-2-oxazoline ( 2) was synthesized from 3,3-dimethylbutyryl chloride and l-valinol in two steps in a total yield of 44%. Reactions of oxazolines 1 and 2 with Pd(OAc) 2 in AcOH or MeCN at different temperatures followed by treatment with LiCl resulted in the formation of the corresponding coordination complexes PdCl 2( 1) 2 and PdCl 2( 2) 2 with no traces of cyclopalladated complexes.