Abstract
Well-defined P4VP-b-PBLG diblock polymer composed of poly (4-vinylpyridine) (P4VP) and poly (γ-benzyl-L-glutamate) (PBLG) was synthesized by click reaction with alkyne- and azide-functionalized homopolymers. Besides, P4VP blocks were synthesized by copper-mediated atom transfer radical polymerization (ATRP) with a chlorine-containing alkyne bifunctional initiator, and the azido-terminated PBLG homopolymers were synthesized by ring-opening polymerization (ROP) of γ-benzyl-L-glutamate with an amine-containing azide initiator. In addition, the synthesized P4VP-b-PBLG with different block ratios has been characterized by proton nuclear magnetic resonance (1H NMR), Gel permeation chromatograph (GPC) and fourier transform infrated spectroscopy (FT-IR). Then, the self-assembly behaviors of P4VP-b-PBLG have been studied by changing parameters like dripping speed and block ratio. The morphologies of self-assembly of spherical, disk-like and ellipsoid-like shape particles have been observed and analyzed by scanning electron microscopy (SEM). These results have provided guidelines for the design of macromolecular self-assembly.
Highlights
Polypeptide copolymer was a kind of block copolymers based on polypeptide-hybrid which consist of polypeptide blocks and other polymer blocks [1] [2]
P4VP blocks were synthesized by copper-mediated atom transfer radical polymerization (ATRP) with a chlorine-containing alkyne bifunctional initiator, and the azido-terminated PBLG homopolymers were synthesized by ring-opening polymerization (ROP) of γ-benzyl-L-glutamate with an amine-containing azide initiator
In this article, ring-opening polymerization of N-carboxyanhydride (NCA-ROP), copper-mediated atom transfer radical polymerization (ATRP) and click reaction were used to synthesize diblock copolymers P4VP-b-PBLG, which were the first examples of diblock copolymers poly (4-vinylpyridine)-b-polypeptide combining pH-stimulating P4VP with biocompatible and biodegradable PBLG
Summary
Polypeptide copolymer was a kind of block copolymers based on polypeptide-hybrid which consist of polypeptide blocks and other polymer blocks [1] [2]. The main chain formed by amide bonds has the characteristic of secondary structure similar to proteins [3]. Polypeptide copolymer differed from traditional copolymer due to the unique sec-. Benefiting from these excellent performances, polypeptide copolymer could offer ideal template materials for macromolecular self-assembly [5] [6]. Peinemann fabricated an integral asymmetric membrane in a fast and one-step process by combining the self-assembly of an amphiphilic block copolymer (PS-b-P4VP) with nonsolvent-induced phase separation. Discovered that amphiphilic polypeptide block copolymers and polypeptide homopolymers PBLG-b-PEG/PBLG were able to aggregate together into super-helical structures of rods and rings Jiaping Lin etc. discovered that amphiphilic polypeptide block copolymers and polypeptide homopolymers PBLG-b-PEG/PBLG were able to aggregate together into super-helical structures of rods and rings
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