Synthesis of oxygenated heterocycles from cyclic allylsiloxanes using ring-closing olefin metathesis

Abstract

Cyclic allylsiloxanes were prepared from allyldimethylsilyl ethers of various alkenols by using a catalytic ring-closing metathesis (RCM) reaction. The transformation of these cyclic allylsiloxanes into stereoselectively substituted tetrahydrofurans and tetrahydropyrans was achieved by using a silyl modified Sakurai reaction.