Abstract
A convenient route to amino acid-based orthogonally protected 1,2-diamines starting from materials readily available for a peptide chemist is presented. The key step of the procedure is the Mitsunobu reaction of N-protected aminoalcohol, obtained by the reduction of commercially available Z- or Boc-protected amino acid, with imidodicarbonate or sulfonylcarbamate related to standard amino-protecting groups used in peptide chemistry yielding triprotected vicinal diamines.
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