Synthesis of organotin complexes with ligands of biological significance

Abstract

A series of new 1:1 complexes of formula Ph 3SnCl·L for a range of ligands L, where L 1 = 2-HOC 6H 4CHNCH 2CO 2Et, L 2 = 2-HOC 6H 4C(CH 3)NCH 2CO 2Et, L 3 = 2HOC 6H 4CHNCH(CH 3)CO 2Me and L 4 = 2-HOC 10H 6CHNCH 2CO 2Et, have been prepared and characterized. A full X-ray crystal structure analysis of the compound chlorotriphenyl(ethyl N-salicylideneglycinate)tin(IV) (Ph 3SnCl·L 1) has been performed. The crystals are monoclinic, space group P21/ n, a = 8.191(4), b = 18.575(5), c = 17.983(7) Å, β = 101.41(4)°, V = 2682.1(18) Å 3, Z = 4, D calc = 1.455 Mg m −3, μ = 1.08 mm −1, final R = 4.3% for 1174 unique observed reflections. It was found that the ligand behaves as a unidentate and binds to the tin via the phenolic oxygen atom. The complexes have a five-coordinated trigonal bipyramidal geometry with the phenyl groups taking up the equatorial position around the tin atom.