Abstract
The first synthesis of bisdifluorocyclopropane derivatives has been accomplished via a chemo-enzymatic reaction strategy; ( E)- or ( Z)-3-tributylstannyl-2-propenols were prepared and their conversion led to the ( trans,trans)- and ( cis,cis)-bisdifluorocyclopropanes. The subsequent lipase-catalyzed reaction efficiently afforded optically active ( trans,trans)-2,2,5,5-tetrafluoro-1,6-bis(hydroxymethyl)bicyclopropane.
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