Abstract
Abstract Fully protected building units for oligodeoxyribonucleotide synthesis in the phosphoramidite approach were prepared in high yields by the 5′-dimethoxytritylation of N-[4,4′,4″-tris(benzoyloxy)trityl]deoxyribonucleosides followed by the 3′-phosphitylation with methoxymorpholinochlorophosphine. The solid phase synthesis of oligodeoxyribonucleotides on a controlled pore glass gel using the amidite units was examined. The efficiency of condensation was discussed in detail. The 4,4′,4″-tris(benzoyloxy)trityl (TBTr) group was removed rapidly from a protected tetramer synthesized on the controlled pore glass gel to give dGpCpApT.
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