Synthesis of Octahydropyrrolo[3,2-c]pyridine Derivatives by the Catalytic Asymmetric Intramolecular Cycloaddition of Azomethine Ylides

Abstract

The synthesis of optically active octahydropyrrolo[3,2-c]pyridine derivatives was achieved via the asymmetric intramolecular cycloaddition of azomethine ylides using copper-bisphosphine complexes. Cu(OTf) 2 -(R,R)-CHIRAPHOS is a suitable catalyst for the reactions.