Synthesis of Nylon 6/Modified Carbon Black Nanocomposites for Application in Uric Acid Adsorption.

Marlene Andrade-Guel,Carlos A Ávila-Orta,Dora A Cortés-Hernández,Fawad Inam,Zoe V Quiñones-Jurado,Pamela Reyes-Rodríguez,Marissa Pérez-Alvarez,Christian J Cabello-Alvarado,Gregorio Cadenas-Pliego

doi:10.3390/ma13225173

Abstract

High uric acid levels cause different clinic conditions. One of them is hyperuricemia, which leads to kidney damage. A solution for eliminating uric acid in the blood is by hemodialysis, which is performed using nanocomposite membranes. In this work, Nylon 6 nanocomposites were synthesized with modified carbon black (MCB), which were considered candidate materials for hemodialysis membranes. The modification of carbon black was made with citric acid using the variable-frequency ultrasound method. The new MCB was characterized by Fourier transform infrared spectroscopy (FTIR), thermogravimetric analysis (TGA), X-ray diffraction (XRD), transmission electron microscopy (TEM), and dispersion tests. Nylon 6/MCB nanocomposites were processed using the ultrasound-assisted melt-extrusion method to improve the dispersion procedure of the nanoparticles. The Nylon 6/MCB nanocomposites were characterized by FTIR, TGA, and differential scanning calorimetry (DSC). These were assessed for the absorption of toxins and hemocompatibility. MBC and nanocomposites showed excellent uric acid removal (78–82%) and hemocompatibility (1.6–1.8%). These results suggest that Nylon 6/MCB nanocomposites with low loading percentages can be used on a large scale without compatibility problems with blood.

Highlights

Cases of hyperuricemia have increased in recent years [1,2]
The results indicate that thermal stability was achieved in unmodified Carbon black (CB), under temperatures ranging from 25 to 150 ◦ C, with a weight loss of only 0.06%, corresponding to the absorbed surface water of material CB
Samples modified with citric acid at different reaction times showed less thermal stability when compared to pure CB, along with weight losses that began at 50 ◦ C and remained constant up to 120 ◦ C

Summary

Introduction

Cases of hyperuricemia have increased in recent years [1,2]. This is linked to people’s lifestyle and the consumption of high-sugar food. It is sometimes a consequence of fructose metabolism in different foods or alcohol, resulting in an increase in uremic acid and leading to hyperuricemia [3]. Materials 2020, 13, 5173 human body: through oral intake or biosynthesis. Oral intake refers to major uric acid consumption, which tends to accumulate in some body parts and reacts through other types of composites produced by the body. Uric acid excess inhibits the generation of nitric oxide, a vasodilator substance, and conduces endothelial dysfunction, which is one of the factors involved in the development of arteriosclerosis [5,6]

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