Synthesis of Novel Virus-Like Mesoporous Silica-ZnO-Ag Nanoparticles and Quercetin Synergize with NIR Laser for Omicron Mutated Covid-19 Virus Infectious Diseases Treatment

Fadi Ibrahim

doi:10.4236/anp.2022.111002

Abstract

This work shows that novel virus-like mesopore silica-zinc oxide/Ag nanoparticles (SZnOAg) synthesized and professionally collected on NIR laser irradiation with quercetin to improve the elimination the mutated virus as a biomedical application. A unique type of silica nanoparticles with a self-in- flating tubular surface has been successfully synthesized using a novel single-micelle epitaxial growth process. The properties of the nanoparticles can be tuned with respect to their core diameter, tubular length, and outer diameter. Due to their biomimetic appearance, they can rapidly transform living cells into virus-like particles, this SZnOAg nanomaterial has specific elimination effect on bacteriophage and Covid-19. Using epitaxial growth, we can construct virus-like structures that can be used for biomedicine applications. These nanomaterials and NIR laser could open the way to a new range of antiviral materials, due to the low-efficiency cellular uptake of current nanoparticles, their applications in the biomedical field are limited. Herein, it clearly shows that novel mesoporous silica nanoparticles can be easily exhibited superior cellular uptake property.

Highlights

This work shows that novel virus-like mesopore silica-zinc oxide/Ag nanoparticles (SZnOAg) synthesized and professionally collected on NIR laser irradiation with quercetin to improve the elimination the mutated virus as a biomedical application
It clearly shows that novel mesoporous silica nanoparticles can be exhibited superior cellular uptake property
Previous reports have introduced various methods to enhance the cellular uptake property by controlling factors that could influence the interaction between nanomaterials and biological hosts, such as chemical composition, particle shape, and surface charge [13] [14] [15] [16]

Summary

Introduction

Their efficiency heavily relies on the cellular uptake performance [6] [7] [8] [9]. Previous reports have introduced various methods to enhance the cellular uptake property by controlling factors that could influence the interaction between nanomaterials and biological hosts, such as chemical composition, particle shape, and surface charge [13] [14] [15] [16]. Ag NPs showed average size of ~15 nm [23]

Methods

Results

Discussion

Conclusion