Abstract
An expedient synthesis of novel triazoles, tetrazine and thiadiazoles, using conveniently accessible and commercially available starting materials has been achieved. The synthesized compounds were characterized by spectroscopic and elemental analyses, and screened for their antibacterial activities against four different strains, namely E. coli, P. aeruginosa, S. aureus and B. megaterium. In particular, the compounds 5, 24 and 26h exhibited excellent antibacterial activities compared to the reference antibiotic. To get further insight about their behavior, these compounds were tested for their antioxidant activities via SOD-like activity, DPPH free radical scavenging activity, ABST and NO, which showed promising results. Furthermore, these compounds effectively promoted the cleavage of genomic DNA as well, in the absence of any external additives.
Highlights
In recent years, heterocyclic compounds have received considerable attention due to their significant importance in pharmacological and agricultural fields [1,2,3,4,5,6,7]
In continuation of our active research in an area of hydrazonoyl halides and their reactions [36,37,38,39,40], a novel compound 4 was prepared by the reaction of salicylaldehyde (1) with phenylhydrazine (2) in boiling ethanol to afford salicylaldehydephenylhydrazone (3, Scheme 1) [41]
When the electron-donating groups such as furan ring is introduced in the compounds, the antioxidant activity is increasedm as reflected by compound 26h, but electron-withdrawing groups such as NO2 or Cl decrease the activity, as observed for 26g or 26e, respectively
Summary
Heterocyclic compounds have received considerable attention due to their significant importance in pharmacological and agricultural fields [1,2,3,4,5,6,7]. 1,2,4-Triazole rings are typically planar 6π-electron aromatic systems and extensive research has been carried out in this domain [10,11] These represent one of the most bioactive classes of compounds, which display diverse biological activities in the medicinal and agrochemical fields, including anti-inflammatory [12,13], antifungal [14,15], herbicidal [16], antimicrobial [16,17], antiparasitic [18], cytostatic [19], and brassinosteroid biosynthesis inhibitory activities [20]. Small heterocyclic molecules that interact with DNA through recognition, binding, crosslinking or cleaving have gained significant attention and are considered as promising area of research in the fields of chemistry, biology and medicine. Such heterocyclic compounds are capable of hydrolyzing and manipulating. Our synthetic investigations towards novel heterocyclic compounds, their biological evaluations and genomic DNA degradation activities are described
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